Manufacture of fine particles and nano particles and coating thereof

An anti-solvent fluid technique is provided that assists in the formation, production and manufacture of fine particles including micro-sized and nanometer-sized particles for a wide variety of bio-medical and pharmaceutical applications. This technique is particularly effective for the manufacturing of polymers/biopolymers/drugs of micron, submicron or nano size as well as particle coating/encapsulation. Co-solvents are used to dissolve the polymer or mixture of polymers to make a solution. The method facilitates rapid drying of precipitated particles with reduced size and agglomerations. The method includes: (1) providing: an anti-solvent fluid; both organic solvents are soluble in the anti-solvent fluid; a second solvent that is at least partially soluble in or miscible with the first solvent; and a solute that is soluble in the first solvent and is substantially insoluble in the second solvent and the anti-solvent fluid; (2) capillary nozzle(s) are used to inject the solution into anti-solvent; (3) contacting the first solvent, the second solvent and the solute together to form a solution; (4) contacting the solution with the anti-solvent fluid to extract both solvents from the solution and precipitate the solute in the form of particles; and (5) contacting the solution with the anti-solvent fluids to extract both solvents from solution and precipitate the solute(s).