Tramadol recovery process

A process for the resolution of isomeric tramadol mixtures comprising: providing a purification stock comprising both cis and trans tramadol; contacting the purification stock with an acid under conditions effective to form an acid salt of the cis and trans tramadol in the purification stock; and se...

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Hauptverfasser: SOUDAGAR SATISH R, SAXENA ASHVINI, DIKE SUNEEL Y, THANKACHEN BYJU N, PATHAK GUNJAN P, PAL VIRENDRA, GEHLOT JAYSINGH, KUMAR ASHOK, KARDE RAHUL, GAUTAM PRASHANT, SARAVANAN MANAVALAN, BURUDKAR SANDEEP M, SHAH CHIRAG H
Format: Patent
Sprache:eng
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Zusammenfassung:A process for the resolution of isomeric tramadol mixtures comprising: providing a purification stock comprising both cis and trans tramadol; contacting the purification stock with an acid under conditions effective to form an acid salt of the cis and trans tramadol in the purification stock; and separating the cis-tramadol acid salt from the trans-tramadol to obtain a purified cis-tramadol acid salt; and optionally converting the cis-tramadol acid salt to cis-tramadol or to a pharmaceutically active salt thereof.