Tramadol recovery process
A process for the resolution of isomeric tramadol mixtures comprising: providing a purification stock comprising both cis and trans tramadol; contacting the purification stock with an acid under conditions effective to form an acid salt of the cis and trans tramadol in the purification stock; and se...
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Format: | Patent |
Sprache: | eng |
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Zusammenfassung: | A process for the resolution of isomeric tramadol mixtures comprising: providing a purification stock comprising both cis and trans tramadol; contacting the purification stock with an acid under conditions effective to form an acid salt of the cis and trans tramadol in the purification stock; and separating the cis-tramadol acid salt from the trans-tramadol to obtain a purified cis-tramadol acid salt; and optionally converting the cis-tramadol acid salt to cis-tramadol or to a pharmaceutically active salt thereof. |
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