Chelate based scaffolds in tumor targeting

This invention relates to novel complexes that can be used to target tumor cells. The complexes include a ligand that can bind metal ions including radioactive lanthanide ions. The complexes can mimic alphanubeta3 integrin receptor antagonists and deliver the complexed radioactive metals to the tumo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	GARLICH JOSEPH R, PATTERSON MARY, SUHR ROBERT G
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	This invention relates to novel complexes that can be used to target tumor cells. The complexes include a ligand that can bind metal ions including radioactive lanthanide ions. The complexes can mimic alphanubeta3 integrin receptor antagonists and deliver the complexed radioactive metals to the tumor cells.