Diaryl Substituted Pyridinones
Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions con...
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| creator | MADSEN HEATHER M NAING WIN WALKER JOHN DEVRAJ RAJESH PROMO MICHELE A MCGEE KEVIN F DURLEY RICHARD C BLEVIS-BAL RADHIKA M OWEN THOMAS SELNESS SHAUN R ALVIRA EDGARDO SHIEH HUEY S JEROME KEVIN D BOEHM TERRI L LIU SHUANG MARRUTO LAURA D HITCHCOCK JEFF SAMBANDAM ARUNA DEVADAS BALEKUDRU HICKORY BRIAN S SCOTT IAN L RUCKER PAUL V XING LI |
| description | Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed. |
| format | Patent |
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These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070419&DB=EPODOC&CC=US&NR=2007088033A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070419&DB=EPODOC&CC=US&NR=2007088033A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MADSEN HEATHER M</creatorcontrib><creatorcontrib>NAING WIN</creatorcontrib><creatorcontrib>WALKER JOHN</creatorcontrib><creatorcontrib>DEVRAJ RAJESH</creatorcontrib><creatorcontrib>PROMO MICHELE A</creatorcontrib><creatorcontrib>MCGEE KEVIN F</creatorcontrib><creatorcontrib>DURLEY RICHARD C</creatorcontrib><creatorcontrib>BLEVIS-BAL RADHIKA M</creatorcontrib><creatorcontrib>OWEN THOMAS</creatorcontrib><creatorcontrib>SELNESS SHAUN R</creatorcontrib><creatorcontrib>ALVIRA EDGARDO</creatorcontrib><creatorcontrib>SHIEH HUEY S</creatorcontrib><creatorcontrib>JEROME KEVIN D</creatorcontrib><creatorcontrib>BOEHM TERRI L</creatorcontrib><creatorcontrib>LIU SHUANG</creatorcontrib><creatorcontrib>MARRUTO LAURA D</creatorcontrib><creatorcontrib>HITCHCOCK JEFF</creatorcontrib><creatorcontrib>SAMBANDAM ARUNA</creatorcontrib><creatorcontrib>DEVADAS BALEKUDRU</creatorcontrib><creatorcontrib>HICKORY BRIAN S</creatorcontrib><creatorcontrib>SCOTT IAN L</creatorcontrib><creatorcontrib>RUCKER PAUL V</creatorcontrib><creatorcontrib>XING LI</creatorcontrib><title>Diaryl Substituted Pyridinones</title><description>Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. 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Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJBzyUwsqsxRCC5NKi7JLCktSU1RCKgsykzJzMvPSy3mYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXxocFGBgbmBhYWBsbGjobGxKkCALE0JdA</recordid><startdate>20070419</startdate><enddate>20070419</enddate><creator>MADSEN HEATHER M</creator><creator>NAING WIN</creator><creator>WALKER JOHN</creator><creator>DEVRAJ RAJESH</creator><creator>PROMO MICHELE A</creator><creator>MCGEE KEVIN F</creator><creator>DURLEY RICHARD C</creator><creator>BLEVIS-BAL RADHIKA M</creator><creator>OWEN THOMAS</creator><creator>SELNESS SHAUN R</creator><creator>ALVIRA EDGARDO</creator><creator>SHIEH HUEY S</creator><creator>JEROME KEVIN D</creator><creator>BOEHM TERRI L</creator><creator>LIU SHUANG</creator><creator>MARRUTO LAURA D</creator><creator>HITCHCOCK JEFF</creator><creator>SAMBANDAM ARUNA</creator><creator>DEVADAS BALEKUDRU</creator><creator>HICKORY BRIAN S</creator><creator>SCOTT IAN L</creator><creator>RUCKER PAUL V</creator><creator>XING LI</creator><scope>EVB</scope></search><sort><creationdate>20070419</creationdate><title>Diaryl Substituted Pyridinones</title><author>MADSEN HEATHER M ; NAING WIN ; WALKER JOHN ; DEVRAJ RAJESH ; PROMO MICHELE A ; MCGEE KEVIN F ; DURLEY RICHARD C ; BLEVIS-BAL RADHIKA M ; OWEN THOMAS ; SELNESS SHAUN R ; ALVIRA EDGARDO ; SHIEH HUEY S ; JEROME KEVIN D ; BOEHM TERRI L ; LIU SHUANG ; MARRUTO LAURA D ; HITCHCOCK JEFF ; SAMBANDAM ARUNA ; DEVADAS BALEKUDRU ; HICKORY BRIAN S ; SCOTT IAN L ; RUCKER PAUL V ; XING LI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2007088033A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2007</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MADSEN HEATHER M</creatorcontrib><creatorcontrib>NAING WIN</creatorcontrib><creatorcontrib>WALKER JOHN</creatorcontrib><creatorcontrib>DEVRAJ RAJESH</creatorcontrib><creatorcontrib>PROMO MICHELE A</creatorcontrib><creatorcontrib>MCGEE KEVIN F</creatorcontrib><creatorcontrib>DURLEY RICHARD C</creatorcontrib><creatorcontrib>BLEVIS-BAL RADHIKA M</creatorcontrib><creatorcontrib>OWEN THOMAS</creatorcontrib><creatorcontrib>SELNESS SHAUN R</creatorcontrib><creatorcontrib>ALVIRA EDGARDO</creatorcontrib><creatorcontrib>SHIEH HUEY S</creatorcontrib><creatorcontrib>JEROME KEVIN D</creatorcontrib><creatorcontrib>BOEHM TERRI L</creatorcontrib><creatorcontrib>LIU SHUANG</creatorcontrib><creatorcontrib>MARRUTO LAURA D</creatorcontrib><creatorcontrib>HITCHCOCK JEFF</creatorcontrib><creatorcontrib>SAMBANDAM ARUNA</creatorcontrib><creatorcontrib>DEVADAS BALEKUDRU</creatorcontrib><creatorcontrib>HICKORY BRIAN S</creatorcontrib><creatorcontrib>SCOTT IAN L</creatorcontrib><creatorcontrib>RUCKER PAUL V</creatorcontrib><creatorcontrib>XING LI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MADSEN HEATHER M</au><au>NAING WIN</au><au>WALKER JOHN</au><au>DEVRAJ RAJESH</au><au>PROMO MICHELE A</au><au>MCGEE KEVIN F</au><au>DURLEY RICHARD C</au><au>BLEVIS-BAL RADHIKA M</au><au>OWEN THOMAS</au><au>SELNESS SHAUN R</au><au>ALVIRA EDGARDO</au><au>SHIEH HUEY S</au><au>JEROME KEVIN D</au><au>BOEHM TERRI L</au><au>LIU SHUANG</au><au>MARRUTO LAURA D</au><au>HITCHCOCK JEFF</au><au>SAMBANDAM ARUNA</au><au>DEVADAS BALEKUDRU</au><au>HICKORY BRIAN S</au><au>SCOTT IAN L</au><au>RUCKER PAUL V</au><au>XING LI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Diaryl Substituted Pyridinones</title><date>2007-04-19</date><risdate>2007</risdate><abstract>Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Diaryl Substituted Pyridinones |
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