Diaryl Substituted Pyridinones

Diaryl Substituted Pyridinones

Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions con...

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Hauptverfasser: MADSEN HEATHER M, NAING WIN, WALKER JOHN, DEVRAJ RAJESH, PROMO MICHELE A, MCGEE KEVIN F, DURLEY RICHARD C, BLEVIS-BAL RADHIKA M, OWEN THOMAS, SELNESS SHAUN R, ALVIRA EDGARDO, SHIEH HUEY S, JEROME KEVIN D, BOEHM TERRI L, LIU SHUANG, MARRUTO LAURA D, HITCHCOCK JEFF, SAMBANDAM ARUNA, DEVADAS BALEKUDRU, HICKORY BRIAN S, SCOTT IAN L, RUCKER PAUL V, XING LI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.