3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands

There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.

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Hauptverfasser: LI GE, FERREIRA JOHAN A, LAI GAIFA, JAKWAY JAMES P, BIJU PURAKKATTLE J, CHAO JIANHUA, LUNDELL DANIEL, TAVERAS ARTHUR G, KAISER BERND, MERRITT J. R, YU YOUNONG, CHAO JIANPING, DWYER MICHAEL, HECKER EVAN A, ROKOSZ LAURA L, WU MINGLANG, NELSON KINGSLEY H.JR, BOND RICHARD W, AKI CYNTHIA J, FINE JAY S, BALDWIN JOHN J
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creator LI GE
FERREIRA JOHAN A
LAI GAIFA
JAKWAY JAMES P
BIJU PURAKKATTLE J
CHAO JIANHUA
LUNDELL DANIEL
TAVERAS ARTHUR G
KAISER BERND
MERRITT J. R
YU YOUNONG
CHAO JIANPING
DWYER MICHAEL
HECKER EVAN A
ROKOSZ LAURA L
WU MINGLANG
NELSON KINGSLEY H.JR
BOND RICHARD W
AKI CYNTHIA J
FINE JAY S
BALDWIN JOHN J
description There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
format Patent
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
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