Chemotherapeutic formulations of zosuquidar trihydrochloride and modified cyclodextrins

The present invention relates to a method of treating patients with leukemias, solid tumors, and other malignancies using chemotherapeutic agents in combination with zosuquidar that has been solubilized by a modified cyclodextrin, such as sulfobutylcyclodextrin or hydroxypropyl cyclodextrin. The inv...

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Hauptverfasser: EDGAR MARK, SCHWEGMAN JEFF, WALSH MICHAEL J, HOTH DANIEL, SOCKS DAVID, SIKIC BRANIMIR, GLENN SCOTT, MARCELLETTI JOHN, MULTANI PRATIK S
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to a method of treating patients with leukemias, solid tumors, and other malignancies using chemotherapeutic agents in combination with zosuquidar that has been solubilized by a modified cyclodextrin, such as sulfobutylcyclodextrin or hydroxypropyl cyclodextrin. The invention is also directed to pharmaceutical formulations comprising zosuquidar in combination with a modified cyclodextrin.