212Bi or 213Bi Generator from supported parent isotope

The invention includes a radionuclide generator having an ion exchange sorbent that comprises oxygen-containing functional groups grafted by organic linking groups to an inorganic oxygen-linked network and a parent isotope. For 212Bi or 213Bi generators, the parent isotope may be 224Ra, 225Ra or 225...

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Bibliographische Detailangaben
Hauptverfasser: CISAR ALAN J, GALI HARIPRASAD
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention includes a radionuclide generator having an ion exchange sorbent that comprises oxygen-containing functional groups grafted by organic linking groups to an inorganic oxygen-linked network and a parent isotope. For 212Bi or 213Bi generators, the parent isotope may be 224Ra, 225Ra or 225Ac. The surface area of the sorbent is preferably less than about 10 m2/g and more preferably less than about 1 m2/g. The exchange sorbent may be formed of any covalently bonded inorganic oxide that is capable of forming oxygen-linked networks. The oxidized functional groups may include sulfonato groups, may include moieties selected from -SO3H, -SO3Na, -SO3K, -SO3Li, -SO3NH4 or may include moieties selected from -PO(OX)2 or -COOX, wherein X is selected from H, Na, K or NH4 or combinations thereof. A 213Bi or 212Bi generator process includes eluting 213Bi or 212Bi with an aqueous solvent that includes 225Ac or 225Ra or 224Ra on the above support medium.