Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders
The present invention relates to antibodies directed to very late antigen-1 ("VLA-1") and uses of such antibodies. For example human monoclonal antibodies directed to VLA-1 are described. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain...
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Zusammenfassung: | The present invention relates to antibodies directed to very late antigen-1 ("VLA-1") and uses of such antibodies. For example human monoclonal antibodies directed to VLA-1 are described. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided. |
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