Vibrio cholerae vaccine candidates, the methods of their constructing and medicinal preparations derived thereof

A single oral administration dose medicinal preparation is derived from Vibrio cholerae vaccine strains which have a disrupted hemagglutinin protease gene and which are tagged with celA coding functions from Clostridium thermocellum are described. The strains are freeze-dried and derived from non to...

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Hauptverfasser:	ROBLES JORGE ANTONIO B, CALZADA RAFAEL A.F, PEREZ TALENA YAMILE L, SILVA CABRERA ANISIA J, GOMEZ JAVIER C, GONZALEZ BORIS LUIS R, DIAZ EDGAR V, HERNANDEZ TOMAS MARCELINO M
Format:	Patent
Sprache:	eng
Schlagworte:	GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Zusammenfassung:	A single oral administration dose medicinal preparation is derived from Vibrio cholerae vaccine strains which have a disrupted hemagglutinin protease gene and which are tagged with celA coding functions from Clostridium thermocellum are described. The strains are freeze-dried and derived from non toxigenic parented strains. The medicinal preparation includes lyopectrants. The single dose of 107 to 109 viable cells/single dose provides effective immunization, with antibacterial antibodies present in about 1 day to a peak activity in about 14 days.