Solvent-free process for preparation of hydrophilic dispersions of nanoparticles of inclusion complexes

The invention provides a solvent-free process for the preparation of a hydrophilic dispersion comprising nanoparticles of an hydrophilic inclusion complex consisting essentially of nanosized particles of an active compound and an amphiphilic polymer which wraps said active compound such that non-valent bonds are formed between said compound and said polymer in said inclusion complex, comprising: (i) preparation of an aqueous solution of the amphiphilic polymer; and (ii) bringing the active compound and the polymer aqueous solution into interaction under conditions suitable for the formation of said hydrophilic dispersion. The process can be applied to small organic compounds as well as to macromolecules, and provides stable hydrophilic dispersions.