Methods to predict ederma as a side effect of drug treatment

This invention provides methods to predict the likelihood of occurrence of the side effect of edema in patients treated with a drug including, but not limited to, a TKI, such as Imatinib or GLEEVEC(TM)/GLIVEC(R). The methods employed use gene expression profile comparisons and the determination of s...

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Hauptverfasser:	MALINOWSKI RACHEL H, KUDARAVALLI SRIDHAR, DRESSMAN MARLENE M, POLYMEROPOULOS MIHAEL H, MCLEAN LEE A
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	This invention provides methods to predict the likelihood of occurrence of the side effect of edema in patients treated with a drug including, but not limited to, a TKI, such as Imatinib or GLEEVEC(TM)/GLIVEC(R). The methods employed use gene expression profile comparisons and the determination of specific SNPs and in the IL-1beta gene. Methods of treatment of edema and kits for the performance of the above assays are also provided.