Substituted indolepyridinium as anti-infective compounds

The present invention concerns the compounds of formula (I) their N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites, wherein n is 1, 2 or 3; R1 is H, CN, halo, aminoC(-O), C(-O)OH, C1-4alkyloxyC(-O), C1-4alkylC(-O), mono- or di(C1-4alkyl)aminoC(-O), arylaminoC...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	KESTELEYN BART R.R, VAN DE VREKEN WIM, DE VROEY VERONIQUE CORINE P, KINDERMANS NATALIE M.F, JOCHMANS DIRK E.D, HERTOGS KURT, BETTENS EVA, CANARD MAXIME FRANCIS J
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention concerns the compounds of formula (I) their N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites, wherein n is 1, 2 or 3; R1 is H, CN, halo, aminoC(-O), C(-O)OH, C1-4alkyloxyC(-O), C1-4alkylC(-O), mono- or di(C1-4alkyl)aminoC(-O), arylaminoC(-O), N-(aryl)-N-(C1-4alkyl)aminoC(-O), methanimidamidyl, N-hydroxy-methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, Het, or Het2; R2 is H, C1-10alkyl, C2-10alkenyl, C3-7cycloalkyl, wherein said C1-10alkyl, C2-10alkenyl and C3-7cycloalkyl may be optionally substituted; R3 is nitro, cyano, amino, halo, hydroxy, C1-4alkyloxy, hydroxyC(-O), aminoC(-O), C1-4alkyloxyC(-O), mono- or di(C1-4alkyl)aminoC(-O), C1-4alkylC(-O), methanimidamidyl, mono- or di(C1-4alkyl)methanimidamidyl, N-hydroxy-methanimidamidyl or Het1; for use as a medicine. The invention further relates to a novel subgroup of the compounds of formula (I), and to compositions comprising compounds of formula (I).