Enzymatic process for the preparation of an intermediate compound and use thereof for the synthesis of tamsulosin hydrochloride

Enzymatic process for the preparation of an intermediate compound and use thereof for the synthesis of tamsulosin hydrochloride

The present invention relates to a process of enantioselective enzymatic acylation for the preparation of (R)-2-halo-N-[2-(4-methoxyphenyl)-1-methyl-ethyl] acetamide compounds, of formula III, in which X-Cl, Br, I. These compounds (III) are useful as intermediates in the synthesis of tamsulosin hydr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: VILLASANTE PRIETO JAVIER, PALOMO NICOLAU FRANCISCO
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present invention relates to a process of enantioselective enzymatic acylation for the preparation of (R)-2-halo-N-[2-(4-methoxyphenyl)-1-methyl-ethyl] acetamide compounds, of formula III, in which X-Cl, Br, I. These compounds (III) are useful as intermediates in the synthesis of tamsulosin hydrochloride.