Acetoacetylation of alcohols, thiols and amines in a microreactor

Acetoacetylation of alcohols, thiols and amines in a microreactor

The invention relates to a method for the production of beta-keto-carboxylic acid derivatives of formula (I) or the salts thereof, where X-NR', O or S, R, R', R1-R4 independently -H, alkyl, alkenyl, aryl or heteroaryl, by reaction of a diketene of formula (II) with a compound comprising an...

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Hauptverfasser: UNVERDORBEN LEONHARD, NICKEL UWE, KIM HIENG, FORSTINGER KLAUS, WEHLE DETLEF
Format: Patent
Sprache:eng
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator UNVERDORBEN LEONHARD
NICKEL UWE
KIM HIENG
FORSTINGER KLAUS
WEHLE DETLEF
description The invention relates to a method for the production of beta-keto-carboxylic acid derivatives of formula (I) or the salts thereof, where X-NR', O or S, R, R', R1-R4 independently -H, alkyl, alkenyl, aryl or heteroaryl, by reaction of a diketene of formula (II) with a compound comprising an active hydrogen of formula ROH, NHRR' or RSH, characterised in that the reaction is continuously carried out in a microreactor.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Acetoacetylation of alcohols, thiols and amines in a microreactor
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