Acetoacetylation of alcohols, thiols and amines in a microreactor

Acetoacetylation of alcohols, thiols and amines in a microreactor

The invention relates to a method for the production of beta-keto-carboxylic acid derivatives of formula (I) or the salts thereof, where X-NR', O or S, R, R', R1-R4 independently -H, alkyl, alkenyl, aryl or heteroaryl, by reaction of a diketene of formula (II) with a compound comprising an...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: UNVERDORBEN LEONHARD, NICKEL UWE, KIM HIENG, FORSTINGER KLAUS, WEHLE DETLEF
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to a method for the production of beta-keto-carboxylic acid derivatives of formula (I) or the salts thereof, where X-NR', O or S, R, R', R1-R4 independently -H, alkyl, alkenyl, aryl or heteroaryl, by reaction of a diketene of formula (II) with a compound comprising an active hydrogen of formula ROH, NHRR' or RSH, characterised in that the reaction is continuously carried out in a microreactor.