Interstitial collagenase molecular motor

A novel interstitial collagenase is disclosed which acts as an ATP-independent molecular motor driven by the proteolysis of substrate collagen. Also disclosed is a method of reacting interstitial collagenase with a collagen fibril to encounter multiple cleavage sites without substantial dissociation...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	SAFFARIAN SAVEEZ, MARMER BARRY L, COLLIER IVAN E, ELSON ELLIOTT L, GOLDBERG GREGORY
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A novel interstitial collagenase is disclosed which acts as an ATP-independent molecular motor driven by the proteolysis of substrate collagen. Also disclosed is a method of reacting interstitial collagenase with a collagen fibril to encounter multiple cleavage sites without substantial dissociation of said interstitial collagenase and thereby act as a molecular motor driven by the proteolysis of substrate collagen. The invention thus is useful as a research tool in the tissue remodeling and cell-matrix interaction. The invention also has significant utility in the screening and development of inhibitors of interstitial collagenase and as a research tool for evaluating the activity and effect of drug candidates.