Allergy vaccine composition, production method thereof and use of same in allergy treatment

The present invention relates to the field of Immunology, specifically with the branch of Immuno-Allergy and in particular with the use of adjuvant or carrier compounds, capable of modulating the immune response to allergens. The technical objective that is pursued is to obtain a pharmaceutical prep...

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Hauptverfasser: PEREZ LASTRE JORGE E, PEREZ MARTIN OLIVER G, PEREZ LASTRE DAINERYS A, BIDOT MARTINEZ IGOR, DEL CAMPO ALONSO JUDITH M, SIERRA GONZALEZ VICTORIANO G, RODRIGUEZ MARTINEZ CLAUDIO, LABRADA ROSADO ALEXIS, FACENDA RAMOS ELISA, ZAYAS VIGNIER CARIDAD, LASTRE GONZALEZ MIRIAM DE SAN JUAN BOSCO, BRACHO GRANADO GUSTAVO R
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Sprache:eng
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Zusammenfassung:The present invention relates to the field of Immunology, specifically with the branch of Immuno-Allergy and in particular with the use of adjuvant or carrier compounds, capable of modulating the immune response to allergens. The technical objective that is pursued is to obtain a pharmaceutical preparation of therapeutic or prophylactic use using bacterial proteoliposomes, which transform the allergic response Th2 and IgE when being applied in allergic individuals, toward a protector response Th1; as well as it is able to prevent the appearance and the development of allergies in individuals non-allergic yet. The vaccine composition consists of proteoliposomes derived from Gram-negative bacteria coupled to allergens and optionally contains other adjuvants or antigens. The method for its preparation and an immunization scheme of two doses are provided.