Methods and compositions for reducing label variation in array-based comparative genome hybridization assays II

Methods and compositions for performing array-based CGH assays are provided. In general, the methods involve evaluating copy number of a genomic region by evaluating binding of distinguishably labeled populations of nucleic acids to a first CGH array in which: a) the populations of nucleic acids are...

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Hauptverfasser: CURRY BO U, ANDERSON PAIGE L
Format: Patent
Sprache:eng
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Zusammenfassung:Methods and compositions for performing array-based CGH assays are provided. In general, the methods involve evaluating copy number of a genomic region by evaluating binding of distinguishably labeled populations of nucleic acids to a first CGH array in which: a) the populations of nucleic acids are labeled by a labeled primer and/or b) binding is assessed relative to binding of dye-swapped populations of nucleic acids to a second CGH array. Kits and systems for use in practicing the subject methods are also provided.