Rapid resolution process of clopidogrel base and a process for preparation of clopidogrel bisulfate polymorph-form I

Rapid resolution process of clopidogrel base and a process for preparation of clopidogrel bisulfate polymorph-form I

The present invention discloses a rapid resolution process of racemic clopidogrel base followed by conversion of the resolved (S) isomer to crystalline Clopidogrel bisulfate Form I. The invention also discloses novel racemization process of the unwanted (R) isomer of clopidogrel base. The invention...

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Hauptverfasser: DESHPANDE MANOJ MADHUKARRAO, TARUR V.R, MONDKAR HARISH KASHNIATH, SAWANT KAMLESH D, SATHE DHANANJAY GOVIND, NAIK TUSHAR ANIL
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention discloses a rapid resolution process of racemic clopidogrel base followed by conversion of the resolved (S) isomer to crystalline Clopidogrel bisulfate Form I. The invention also discloses novel racemization process of the unwanted (R) isomer of clopidogrel base. The invention further discloses an improved process for preparation of acid addition salts of clopidogrel.