Method of treating inflammation with inhibitors of sialyl transferases

Provided herein are a methods of reducing a level of activity of a sialyl transferase enzyme, a sialidase enzyme or a combination thereof using inhibitors of these enzymes, for example specific inhibitory compound or antibodies directed against the enzymes. The methods are effective to treat an infl...

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Bibliographische Detailangaben
Hauptverfasser: STAMATOS NICHOLAS M, CROSS ALAN S, GOLDBLUM SIMEON E
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:Provided herein are a methods of reducing a level of activity of a sialyl transferase enzyme, a sialidase enzyme or a combination thereof using inhibitors of these enzymes, for example specific inhibitory compound or antibodies directed against the enzymes. The methods are effective to treat an inflammatory disease or disorder or a primary or metastatic cancer. Also provided is a method for screening potential inhibitors of sialyl transferase enzymes.