Process for preparing simvastatin having controlled ranges of simvastatin dimer content

The present invention relates to a process for preparing simvastatin, wherein the simvastatin dimer content is controlled. More particularly, the present invention relates to a process for preparing simvastatin having a simvastatin dimer content of about 0.2 to about 0.4 % wt. The present invention...

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Bibliographische Detailangaben
Hauptverfasser: SZABO CSABA, KORODI FERENC, SALYI SZABOLCS, BODI ISTVAN
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to a process for preparing simvastatin, wherein the simvastatin dimer content is controlled. More particularly, the present invention relates to a process for preparing simvastatin having a simvastatin dimer content of about 0.2 to about 0.4 % wt. The present invention also relates to a process for preparing simvastatin having a simvastatin dimer content of less than about 0.2% wt. The present invention also discloses a commercial scale process of preparing simvastatin having a specified simvastatin dimer content which is reproducible.