Methods for inducing apolipoprotein e secretion

The invention provides a method for increasing apolipoprotein E (ApoE) in plasma and in tissues of a mammal by using a combination of an ApoE increasing amount of an activator of the orphan nuclear receptor FXR and an ApoE increasing amount of an activator of the orphan nuclear receptor LXRalpha. Al...

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Bibliographische Detailangaben
Hauptverfasser:	BENTZEN CRAIG L, THUILLARD JEAN-LUC, NGUYEN LAN M, NIESOR ERIC J, PEREZ ANE
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The invention provides a method for increasing apolipoprotein E (ApoE) in plasma and in tissues of a mammal by using a combination of an ApoE increasing amount of an activator of the orphan nuclear receptor FXR and an ApoE increasing amount of an activator of the orphan nuclear receptor LXRalpha. Also provided is the use of a combination of an ApoE increasing amount of a FXR activator and of an ApoE increasing amount of a LXRalpha activator, for the manufacture of a medicament for increasing ApoE in plasma and in tissues of a mammal.