Cleavage of VEGF and VEGF receptor by wildtype and mutant MT-SP1

MT-SP1 mutein proteases with altered specificity for the target molecules they cleave can be used to treat human diseases, such as cancer. Cleaving VEGF or VEGFR at certain substrate sequences with wild-type and mutein MT-SP1 proteases can be used to treat pathologies associated with angiogenesis.

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Bibliographische Detailangaben
Hauptverfasser: NGUYEN JACK, RUGGLES SANDRA W
Format: Patent
Sprache:eng
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Zusammenfassung:MT-SP1 mutein proteases with altered specificity for the target molecules they cleave can be used to treat human diseases, such as cancer. Cleaving VEGF or VEGFR at certain substrate sequences with wild-type and mutein MT-SP1 proteases can be used to treat pathologies associated with angiogenesis.