Ansamycins having improved pharmacological and biological properties

Ansamycins and methods of preparing and using the same are described. At least some of these ansamycins exhibit one or more of improved aqueous formulation ability, chemical stability, and bioavailability. Some of the derivatives described are dimers. These and others described can include one or mo...

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Bibliographische Detailangaben
Hauptverfasser: BURROWS FRANCIS J, FRITZ LAWRENCE C, LE BRAZIDEC JEAN-YVES, BOEHM MARCUS F, MCHUGH SEAN K, ZHANG LIN, FAN JUNHUA
Format: Patent
Sprache:eng
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Zusammenfassung:Ansamycins and methods of preparing and using the same are described. At least some of these ansamycins exhibit one or more of improved aqueous formulation ability, chemical stability, and bioavailability. Some of the derivatives described are dimers. These and others described can include one or more solubilizing groups that have expected merit in rendering the overall compounds useful as drugs and prodrugs.