Aerosol drug delivery system employing formulation pre-heating

A formulation of a drug in a liquid carrier is heated in a controlled fashion and then aerosolized. The aerosolized formulation comprises particles having an aerodynamic diameter in a range of about 0.5 to about 12 micrometers. The particles are inhaled into the lungs of a human patient thereby deli...

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Bibliographische Detailangaben
Hauptverfasser:	CIPOLLA DAVID, NOYMER PETER D, BOYD BROOKS M, MURATORE JUSTIN D
Format:	Patent
Sprache:	eng
Schlagworte:	DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE
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Beschreibung
Zusammenfassung:	A formulation of a drug in a liquid carrier is heated in a controlled fashion and then aerosolized. The aerosolized formulation comprises particles having an aerodynamic diameter in a range of about 0.5 to about 12 micrometers. The particles are inhaled into the lungs of a human patient thereby delivering drug to the patient. By heating the formulation prior to aerosolization, the viscosity of the formulation is reduced thereby improving delivery efficiency. Repeatability of aerosol formation is improved by pre-heating the solution to the same or substantially the same temperature for successive delivery events.