Sodium channel regulators and modulators

The present invention provides a method of identifying a modulator of a voltage gated sodium channel (VGSC), which method comprises: (a) bringing into contact a test compound, a VGSC and one or more binding partners selected from PAPIN, periaxin and HSPC025 under conditions where the VGSC and the bi...

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Bibliographische Detailangaben
Hauptverfasser:	BAKER MARK, WOOD JOHN N, OKUSE KENJI, POON LOUISA, MALIK-HALL MISBAH
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The present invention provides a method of identifying a modulator of a voltage gated sodium channel (VGSC), which method comprises: (a) bringing into contact a test compound, a VGSC and one or more binding partners selected from PAPIN, periaxin and HSPC025 under conditions where the VGSC and the binding partner(s) are capable of forming a complex in the absence of the test compound; and (b) measuring an activity of the VGSC, wherein a charge in the activity of the VGSC relative to the activity in the absence of the test compound indicates that the test compound is a modulator of said VGSC. Compounds identified in such screening methods are proposed for use in the treatment of VGSC-related conditions, for example in the treatment or prevention of pain. Also provided are methods of enhancing the functional expression of a voltage gated sodium channel (VGSC) in a cell comprising the step of increasing the level of a binding partner of the invention in the cell.