Methods for the identification of inhibitors of amidophosphoribosyltransferase as antibiotics

The present inventors have discovered that amidophosphoribosyltransferase is essential for normal fungal pathogenicity. Specifically, the inhibition of amidophosphoribosyltransferase gene expression in fungi results in drastically reduced pathogenicity. Thus, amidophosphoribosyltransferase can be us...

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Bibliographische Detailangaben
Hauptverfasser:	LO SZEUNG C, PAN HUAQIN, TANZER MATTHEW M, COVINGTON AMY S, HEINIGER RYAN W, DARVEAUX BLAISE A, TARPEY REX, HAMER LISBETH, MONTENEGROAMORRO MARIA V, SHUSTER JEFFREY R, ADACHI KIICHI, FRANK SHERYL A, DEZWAAN TODD M, MAHANTY SANJOY K
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present inventors have discovered that amidophosphoribosyltransferase is essential for normal fungal pathogenicity. Specifically, the inhibition of amidophosphoribosyltransferase gene expression in fungi results in drastically reduced pathogenicity. Thus, amidophosphoribosyltransferase can be used as a target for the identification of antibiotics, preferably antifungals. Accordingly, the present invention provides methods for the identification of compounds that inhibit amidophosphoribosyltransferase expression or activity. The methods of the invention are useful for the identification of antibiotics, preferably antifungals.