Inhibitors of protein tyrosine phosphatase 1B
Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted bicyclic fused-thiophene compounds can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provi...
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| creator | XU WEIXIN LEE JINBO TAM STEVE Y KIRINCICH STEVE J FOLLOWS BRUCE C WAN ZHAO-KUI JOSEPH-MCCARTHY DIANE M ERBE DAVID V SMITH MICHAEL J ZHANG YAN-LING WILSON DOUGLAS P |
| description | Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted bicyclic fused-thiophene compounds can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes. |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Inhibitors of protein tyrosine phosphatase 1B |
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