Inhibitors of protein tyrosine phosphatase 1B

Inhibitors of protein tyrosine phosphatase 1B

Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted bicyclic fused-thiophene compounds can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provi...

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Bibliographische Detailangaben
Hauptverfasser: XU WEIXIN, LEE JINBO, TAM STEVE Y, KIRINCICH STEVE J, FOLLOWS BRUCE C, WAN ZHAO-KUI, JOSEPH-MCCARTHY DIANE M, ERBE DAVID V, SMITH MICHAEL J, ZHANG YAN-LING, WILSON DOUGLAS P
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Protein tyrosine phosphatases (PTPases) such as PTP1B can play a role in regulating a wide variety of cellular responses such as insulin signaling. Substituted bicyclic fused-thiophene compounds can inhibit PTP1B and thereby induce greater insulin sensitivity. Accordingly, PTP1B inhibition can provide an alternate treatment for PTPase-mediated disorders such as diabetes.