Pregnancy up-regulated, nonubiquitous CaM kinase

This invention relates generally to a novel CaM multi-functional protein kinase, which has been named Pregnancy Up-Regulated, Nonubiquitous CaM Kinase (PNCK), and to the nucleotide sequence encoding it. The kinase is temporally expressed during postnatal mammary development in a spatially heterogene...

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Bibliographische Detailangaben
Hauptverfasser:	GARDNER HEATHER P, CHODOSH LEWIS A
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMES ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	This invention relates generally to a novel CaM multi-functional protein kinase, which has been named Pregnancy Up-Regulated, Nonubiquitous CaM Kinase (PNCK), and to the nucleotide sequence encoding it. The kinase is temporally expressed during postnatal mammary development in a spatially heterogeneous manner in certain subsets of cells, and overexpressed in a subset of primary breast cancers. The invention further relates to an analysis of a correlation between carcinogenesis and postnatal development, particularly mammary development, especially associated with parity; as well as to methods of using the kinase, or gene encoding it, as markers, prognostic tools, screening tools and therapies, in vitro and in vivo that are based upon that correlation.