Methods of detecting human diseases using a human genomic polynucleotide

Methods of detecting human diseases using a human genomic polynucleotide

Murine cDNA encoding the alpha1 subunit of soluble guanylyl cyclase (sGC) and additional sequence to the known 3' noncoding part of beta1 subunit of soluble guanylyl cyclase are identified herein. The new genes are further used for expression of encoded proteins. The new part of the beta1 cDNA...

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Hauptverfasser: SHARINA IRAIDA G, MARTIN EMIL, MURAD FERID, KRUMENACKER JOSHUA S
Format: Patent
Sprache:eng
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Zusammenfassung:Murine cDNA encoding the alpha1 subunit of soluble guanylyl cyclase (sGC) and additional sequence to the known 3' noncoding part of beta1 subunit of soluble guanylyl cyclase are identified herein. The new genes are further used for expression of encoded proteins. The new part of the beta1 cDNA sequences is further used for screening of regulatory factors associated with modulation of the expression of the beta1 sGC subunit.