Human interferon-beta formulations

The invention provides a stable pharmaceutical composition containing biologically active human interferon-beta (IFN-beta), preferably IFN beta-1b produced in a bacterial host, dissolved in an aqueous-based solution containing a glycine buffer at a pH of about 2.0 to about 4.0. The invention of also...

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Bibliographische Detailangaben
Hauptverfasser:	MCCAMAN MICHAEL, PUNGOR ERNO, OTTOBONI SUSANNE
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention provides a stable pharmaceutical composition containing biologically active human interferon-beta (IFN-beta), preferably IFN beta-1b produced in a bacterial host, dissolved in an aqueous-based solution containing a glycine buffer at a pH of about 2.0 to about 4.0. The invention of also provides stable IFN-beta lyophilizates prepared from biologically active IFN-beta, dissolved in an aqueous-based solution containing a glycine buffer at a pH of about 2.0 to about 4.0.