Small molecule compositions and methods for increasing drug efficiency using compositions thereof
In certain embodiments, provided herein are compositions and methods for increasing drug efficiency. The conjugates provided are in certain embodiments, for compositions and methods in treatment of variety of diseases and have the formula 1: D-L-S (1) or formula 2: D-L-S' (2) wherein D is a dru...
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| creator | CASTELLINO ANGELO J DESHARNAIS JOEL SUN CHENGZAO ASPLAND SIMON E NEWMAN MICHAEL J WIRSCHING PETER BALLATORE CARLO |
| description | In certain embodiments, provided herein are compositions and methods for increasing drug efficiency. The conjugates provided are in certain embodiments, for compositions and methods in treatment of variety of diseases and have the formula 1: D-L-S (1) or formula 2: D-L-S' (2) wherein D is a drug moiety; L, which may or may not be present, is a non-releasing linker moiety; S is a substrate for a kinase, other than a hexokinase, a protein kinase or a lipid kinase; and S' is a substrate for a phosphotransferase, other than a hexokinase, a protein kinase or a lipid kinase. |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Small molecule compositions and methods for increasing drug efficiency using compositions thereof |
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