Small molecule compositions and methods for increasing drug efficiency using compositions thereof

Small molecule compositions and methods for increasing drug efficiency using compositions thereof

In certain embodiments, provided herein are compositions and methods for increasing drug efficiency. The conjugates provided are in certain embodiments, for compositions and methods in treatment of variety of diseases and have the formula 1: D-L-S (1) or formula 2: D-L-S' (2) wherein D is a dru...

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Bibliographische Detailangaben
Hauptverfasser: CASTELLINO ANGELO J, DESHARNAIS JOEL, SUN CHENGZAO, ASPLAND SIMON E, NEWMAN MICHAEL J, WIRSCHING PETER, BALLATORE CARLO
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:In certain embodiments, provided herein are compositions and methods for increasing drug efficiency. The conjugates provided are in certain embodiments, for compositions and methods in treatment of variety of diseases and have the formula 1: D-L-S (1) or formula 2: D-L-S' (2) wherein D is a drug moiety; L, which may or may not be present, is a non-releasing linker moiety; S is a substrate for a kinase, other than a hexokinase, a protein kinase or a lipid kinase; and S' is a substrate for a phosphotransferase, other than a hexokinase, a protein kinase or a lipid kinase.