Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-one compounds and intermediates thereof

Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-one compounds and intermediates thereof

A process is provided for the preparation of compounds of formula (I) herein comprising reacting a compound of formula (II), (III), (IV) or (V) in the presence of -OR3 and a hydroxide trapping agent or in the case of compounds of formula (IV) reacting in the presence of an auxiliary base and a hydro...

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Bibliographische Detailangaben
Hauptverfasser: LEVETT PHILIP C, RAWSON DAVID J, DEVRIES KEITH M, ALLERTON CHARLOTTE MOIRA N, BARBER CHRISTOPHER G, HARRIS LAURENCE J, NEGRI JOANNA T, WOOD ALBERT S
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:A process is provided for the preparation of compounds of formula (I) herein comprising reacting a compound of formula (II), (III), (IV) or (V) in the presence of -OR3 and a hydroxide trapping agent or in the case of compounds of formula (IV) reacting in the presence of an auxiliary base and a hydroxide trapping agent ( i.e. -OR3 is substituted by the auxiliary base), wherein X is a leaving group and R1 to R4 are as defined.