Hydrophobically-modified protein compositions and methods

Hydrophobically-modified protein compositions and methods

Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that...

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Bibliographische Detailangaben
Hauptverfasser: PEPINSKY R. B, PORTER JEFFERY, GALDES ALPHONSE, WILLIAMS KEVIN P, WEN DINGYI, ZENG CHENHUI, TAYLOR FREDERICK R, BAKER DARREN P, STRAUCH KATHRYN L, GARBER ELLEN A, PETTER RUSSELL C, WEINREB PAUL H
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Hydrophobically-modified proteins and methods of making them are described. A hydrophobic moiety is attached to a surface amino acid residue of the protein. The hydrophobic moiety can be a lipid or a peptide. Alternatively, the protein can be derivatized by a wide variety of chemical reactions that append a hydrophobic structure to the protein. The preferred protein is of mammalian origin and is selected from the group consisting of Sonic, Indian, and Desert hedgehog. The hydrophobic moiety is used as a convenient tether to which may be attached a vesicle such as a cell membrane, liposome, or micelle.