Method for expressing multiple recombinant proteins in milk of transgenic non-human mammals

Method for expressing multiple recombinant proteins in milk of transgenic non-human mammals

The present invention discloses a method for expressing multiple recombinant proteins in transgenic non-human mammalian milk, characterized in which human clotting factor IX gene and porcine lactoferrin gene are transferred into the mammal by gene injection and embryonic implantation to obtain expre...

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Hauptverfasser: CHENG TENG-KUEI W, LIN SHAU-PING, YEN CHON-HO, WU SHINNIH, CHEN CHUAN-MU, YANG PINGNG
Format: Patent
Sprache:eng
Schlagworte:
AGRICULTURE
ANIMAL HUSBANDRY
CARE OF BIRDS, FISHES, INSECTS
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
NEW BREEDS OF ANIMALS
REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR
TRAPPING
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creator CHENG TENG-KUEI W
LIN SHAU-PING
YEN CHON-HO
WU SHINNIH
CHEN CHUAN-MU
YANG PINGNG
description The present invention discloses a method for expressing multiple recombinant proteins in transgenic non-human mammalian milk, characterized in which human clotting factor IX gene and porcine lactoferrin gene are transferred into the mammal by gene injection and embryonic implantation to obtain expression in the milk of transgenic mammal and its filial generation. The method of this invention can maintain the stable expression of multiple recombinant proteins in the transgenic mammal during lactation and stable expression amount proximate to that of the first generation in the offsprings of the transgenic non-human mammal.
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The method of this invention can maintain the stable expression of multiple recombinant proteins in the transgenic mammal during lactation and stable expression amount proximate to that of the first generation in the offsprings of the transgenic non-human mammal.</description><edition>7</edition><language>eng</language><subject>AGRICULTURE ; ANIMAL HUSBANDRY ; CARE OF BIRDS, FISHES, INSECTS ; FISHING ; FORESTRY ; HUMAN NECESSITIES ; HUNTING ; NEW BREEDS OF ANIMALS ; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR ; TRAPPING</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20050526&amp;DB=EPODOC&amp;CC=US&amp;NR=2005114911A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20050526&amp;DB=EPODOC&amp;CC=US&amp;NR=2005114911A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHENG TENG-KUEI W</creatorcontrib><creatorcontrib>LIN SHAU-PING</creatorcontrib><creatorcontrib>YEN CHON-HO</creatorcontrib><creatorcontrib>WU SHINNIH</creatorcontrib><creatorcontrib>CHEN CHUAN-MU</creatorcontrib><creatorcontrib>YANG PINGNG</creatorcontrib><title>Method for expressing multiple recombinant proteins in milk of transgenic non-human mammals</title><description>The present invention discloses a method for expressing multiple recombinant proteins in transgenic non-human mammalian milk, characterized in which human clotting factor IX gene and porcine lactoferrin gene are transferred into the mammal by gene injection and embryonic implantation to obtain expression in the milk of transgenic mammal and its filial generation. 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subjects AGRICULTURE
ANIMAL HUSBANDRY
CARE OF BIRDS, FISHES, INSECTS
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
NEW BREEDS OF ANIMALS
REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR
TRAPPING
title Method for expressing multiple recombinant proteins in milk of transgenic non-human mammals
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