Method for expressing multiple recombinant proteins in milk of transgenic non-human mammals

The present invention discloses a method for expressing multiple recombinant proteins in transgenic non-human mammalian milk, characterized in which human clotting factor IX gene and porcine lactoferrin gene are transferred into the mammal by gene injection and embryonic implantation to obtain expre...

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Bibliographische Detailangaben
Hauptverfasser:	CHENG TENG-KUEI W, LIN SHAU-PING, YEN CHON-HO, WU SHINNIH, CHEN CHUAN-MU, YANG PINGNG
Format:	Patent
Sprache:	eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY CARE OF BIRDS, FISHES, INSECTS FISHING FORESTRY HUMAN NECESSITIES HUNTING NEW BREEDS OF ANIMALS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR TRAPPING
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Beschreibung
Zusammenfassung:	The present invention discloses a method for expressing multiple recombinant proteins in transgenic non-human mammalian milk, characterized in which human clotting factor IX gene and porcine lactoferrin gene are transferred into the mammal by gene injection and embryonic implantation to obtain expression in the milk of transgenic mammal and its filial generation. The method of this invention can maintain the stable expression of multiple recombinant proteins in the transgenic mammal during lactation and stable expression amount proximate to that of the first generation in the offsprings of the transgenic non-human mammal.