Heteroarylalkanoic acids as integrin receptor antagonists derivatives

The present invention relates to pharmaceutical compositions comprising compounds of the Formula I, or a pharmaceutically acceptable salt thereof, and methods of selectively inhibiting or antagonizing the alphaVbeta3 and/or the alphaVbeta5 integrin without significantly inhibiting the alphaVbeta6 in...

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Bibliographische Detailangaben
Hauptverfasser:	PENNING THOMAS D, MOHLER SCOTT B, WU HONGWEI, SCHRETZMAN LORI A, STENMARK HEATHER, LU HWANG-FUN, DEVADAS BALEKUDRU, DOWNS VICTORIA L, SPANGLER DALE P, DESAI BIPINCHANDRA N, KHANNA ISH KUMAR, BOYS MARK L, GESICKI GLEN J, CHEN BARBARA B, HUFF RENEE M, NAGARAJAN SRINIVASAN RAJ, CHANDRAKUMAR NIZAL SAMUEL, WANG YAPING, RUSSELL MARK, KHILEVICH ALBERT, YU YI, NGUYEN MARIA, PARIKH MIHIR D, WENDT JOHN A, TOLLEFSON MICHAEL B
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to pharmaceutical compositions comprising compounds of the Formula I, or a pharmaceutically acceptable salt thereof, and methods of selectively inhibiting or antagonizing the alphaVbeta3 and/or the alphaVbeta5 integrin without significantly inhibiting the alphaVbeta6 integrin.