Thiazole compounds as integrin receptor antagonists derivatives

Thiazole compounds as integrin receptor antagonists derivatives

The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the alphavbeta3 and/or the alphavbeta5 integrin w...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CHEN BARBARA B, PENNING THOMAS D, RUSSELL MARK, DOWNS VICTORIA L, WU HONGWEI, SPANGLER DALE P, WANG YAPING, WENDT JOHN A, STENMARK HEATHER, BOYS MARK L
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the alphavbeta3 and/or the alphavbeta5 integrin without significantly inhibiting the alphavbeta6 integrin.