Pyrimidine derivatives useful as inhibitors of PKC-theta

Disclosed are novel compounds of formula (I): wherein R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disord...

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Hauptverfasser: CARDOZO MARIO G, COGAN DEREK, PROKOPOWICZ ANTHONY S, SPERO DENICE M, CYWIN CHARLES LAWRENCE, GINN JOHN DAVID, YOUNG ERICK, DAHMANN GEORG, DISALVO DARREN
Format: Patent
Sprache:eng
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Zusammenfassung:Disclosed are novel compounds of formula (I): wherein R1, R2 and R3 are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, including immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.