Controlling distribution of epitopes in polypeptide sequences

The present invention describes a novel method for the design of polypeptides with controlled distribution of immunogentic epitopes. The method allows for the controlled elimination or introductionof epitopes in consideration of major histocompatibility complex (MHC) molecule binding motifs.

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Bibliographische Detailangaben
Hauptverfasser:	SUMMERS NEENA L, LEE STEPHEN C
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING
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Beschreibung
Zusammenfassung:	The present invention describes a novel method for the design of polypeptides with controlled distribution of immunogentic epitopes. The method allows for the controlled elimination or introductionof epitopes in consideration of major histocompatibility complex (MHC) molecule binding motifs.