Control of glycoforms in IgG

The present invention provides a method to control the level of non-glycosylated heavy chain variant of an IgG in a CHO cell culture process by adjusting temperature and batched medium osmolality.

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Bibliographische Detailangaben
Hauptverfasser:	DEVRIES RUTH L, VICKROY THOMAS BRUCE
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The present invention provides a method to control the level of non-glycosylated heavy chain variant of an IgG in a CHO cell culture process by adjusting temperature and batched medium osmolality.