Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus

Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus

Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-en...

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Hauptverfasser: DIEBELE HEATHER L. M, DOBRY DAN E, BEYERINCK RONALD A, RAY RODERICK J, SETTELL DANA M, SPENCE KEN R
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.