Formulations of low solubility bioactive agents and processes for making the same

Formulations of low solubility bioactive agents and processes for making the same

A method of coprocessing a limited solubility bioactive agent with a compatible aid comprising: (a) identifying a compatible aid for the bioactive agent; (b) either (i) forming a co-dissolved solution of the compatible aid and bioactive agent in a common solvent or (ii) forming a solution of the com...

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Hauptverfasser: WEI CHENKOU, KIM SOOJIN, HSIEH ALICE HUEY-MEI, HARLAND RONALD
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator WEI CHENKOU
KIM SOOJIN
HSIEH ALICE HUEY-MEI
HARLAND RONALD
description A method of coprocessing a limited solubility bioactive agent with a compatible aid comprising: (a) identifying a compatible aid for the bioactive agent; (b) either (i) forming a co-dissolved solution of the compatible aid and bioactive agent in a common solvent or (ii) forming a solution of the compatible aid in an anti-solvent and forming solution of the bioactive agent in a solvent; and (c) forming a film or primary particles from the co-dissolved solution or solutions of step (b), which film or primary particles comprise bioactive agent in crystalline form, with the crystals having average diameter of 1 micron or less.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Formulations of low solubility bioactive agents and processes for making the same
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