Formulations of low solubility bioactive agents and processes for making the same
A method of coprocessing a limited solubility bioactive agent with a compatible aid comprising: (a) identifying a compatible aid for the bioactive agent; (b) either (i) forming a co-dissolved solution of the compatible aid and bioactive agent in a common solvent or (ii) forming a solution of the com...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | A method of coprocessing a limited solubility bioactive agent with a compatible aid comprising: (a) identifying a compatible aid for the bioactive agent; (b) either (i) forming a co-dissolved solution of the compatible aid and bioactive agent in a common solvent or (ii) forming a solution of the compatible aid in an anti-solvent and forming solution of the bioactive agent in a solvent; and (c) forming a film or primary particles from the co-dissolved solution or solutions of step (b), which film or primary particles comprise bioactive agent in crystalline form, with the crystals having average diameter of 1 micron or less. |
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