Anticoagulants and their uses

The present invention relates to the identification of a specific inhibitor of the extrinsic clotting pathway from triatomine bugs, which we have designated TEPI (triatomine extrinsic pathway inhibitor). In one embodiment, the polypeptide inhibitor or fragment has a N-terminal sequence: wherein X in...

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Bibliographische Detailangaben
Hauptverfasser:	MORRIS MICHAEL, MUNRO ROGER, ELECTRICWALA ASGAR, SICARD NILS VON
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to the identification of a specific inhibitor of the extrinsic clotting pathway from triatomine bugs, which we have designated TEPI (triatomine extrinsic pathway inhibitor). In one embodiment, the polypeptide inhibitor or fragment has a N-terminal sequence: wherein X indicates any amino acid sequence residue or pharmaceutically acceptable salt thereof and A represents Ser, Asp or Glu, and preferably Ser.