Process for the preparation of 4-amino-1-hydroxybutylidene-1,1-biphosphonic acid

Process for the preparation of 4-amino-1-hydroxybutylidene-1,1-biphosphonic acid

This invention is related with the preparation of 4-amino-1-hydroxybutylidene-1,1-biphosphonic acid or salts thereof. The reaction of 4-aminobutyric acid with phosphorous acid and phosphorous thrichloride in the presence of aralkyl or akyl ethoxylates or triglycerides such as plant or animal oils or...

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Bibliographische Detailangaben
Hauptverfasser: OZARSLAN A EVREN, DABAK KADIR, SAHBAZ FILIZ, ASLAN TUNCER
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:This invention is related with the preparation of 4-amino-1-hydroxybutylidene-1,1-biphosphonic acid or salts thereof. The reaction of 4-aminobutyric acid with phosphorous acid and phosphorous thrichloride in the presence of aralkyl or akyl ethoxylates or triglycerides such as plant or animal oils or their derivative; and recovering of 4-amino-1-hydroxybutylidene-1,1-biphosphonic acid or salts thereof are described. The main feature of the invention is in the use of the above defined non-ionic emulgators in the phosphonylation reaction.