Device and method for evaluating platelets

A method and apparatus are disclosed for measuring platelet activation in a whole blood matrix under physiological conditions and independent of the activation of a coagulation cascade in the plasma. The method and system measure the propensity of cells in a biological fluid to form adherent cell aggregates and thrombin. The method accommodates both citrated and native venous blood. The system includes a simple, low-cost, single-use thrombogenic test cartridge for measuring the intensity of thrombus formation, and for providing quantitative measurement of platelet functions in a near-patient environment. Hemostatic activity of platelets in a biological fluid sample is assessed by monitoring the degree of adherent thrombus formation after cells are exposed to platelet agonists in a shear stress environment. The system may be configured to monitor the therapeutic effects of anti-platelet agents, to assess primary hemostatic response of platelets, and to assess thrombotic potential of platelets.